সোমবার, ২৯ এপ্রিল, ২০১৩

What do you want to see in iMore app 3.0?

What do you want to see in iMore app 3.0?

iMore for iPhone version 2.0 only just launched but we're already in the early stages of work on iMore app 3.0 and one of the very first things we wanted to do was ask you, the iMore community, what you want to see?

We'll be doing some obvious architectural things, like switching from Drupal-based authentication to our awesome new Mobile Nations Passport system, and moving things like text size selectors to a dedicated settings screen so your choice persists once you make it. But we'd love to hear from you on some of the other options.

For example, would you like to see an iPad interface? iMore is a website and the iPad has a great, full-sized web browser, so would an app version of the site really make a big difference to you? Would things like the favorites, podcasts, and tab-based sorting make your iMore-on-iPad experience better?

Search is something else that we get a lot of requests for. However, we wouldn't want to cache the entire 5+ years of iMore on your iPhone, so that means web-based search is the only practical alternative, and again, is that something that's better done in the browser?

We currently push comments off into a second screen so loading them doesn't slow down the main article, but is that convenient for you, or just one extra tap too many?

What about the iMore Forums? Right now they're in a separate app, but would it better for you if we bundled them together into one super iMore app?

What about the overall design? Is there anything we could do there to make your experience better?

iMore, Nickelfish, and everyone at Mobile Nations is dedicated to making the next version of the iMore app absolutely the best ever, so let us know -- what do you want to see?

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/myXZ8lqvfes/story01.htm

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Happy 32nd Birthday, Jessica Alba!

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Kobo Aura HD Review: A Beautiful Reader Screen Trapped in an Ugly Body

Everyone loves a pretty screen. The Kobo Aura HD is aiming to lead that charge in the ereader space. Armed with a best-in-class screen and an unusually powerful processor under the hood, the Aura HD tries its best to be a real luxury reader. It doesn't quite make it.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/qXzOI_dwVQg/kobo-aura-hd-review-a-beautiful-reader-screen-trapped-5995330

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Lawmakers: Syria chemical weapons could menace US

WASHINGTON (AP) ? Syria's stockpile of chemical weapons could be a greater threat after that nation's president leaves power and could end up targeting Americans at home, lawmakers warned Sunday as they considered a U.S. response that stops short of sending military forces there.

U.S. officials last week declared that the Syrian government probably had used chemical weapons twice in March, newly provocative acts in the 2-year civil war that has killed more than 70,000 people and displaced hundreds of thousands more. The U.S. assessment followed similar conclusions from Britain, France, Israel and Qatar ? key allies eager for a more aggressive response to the Syrian conflict.

President Barack Obama has said Syria's likely action ? or the transfer of President Bashar Assad's stockpiles to terrorists ? would cross a "red line" that would compel the United States to act.

Lawmakers sought to remind viewers on Sunday news programs of Obama's declaration while discouraging a U.S. foothold on the ground there.

"The president has laid down the line, and it can't be a dotted line. It can't be anything other than a red line," said House Intelligence Committee Chairman Rep. Mike Rogers, R-Mich. "And more than just Syria, Iran is paying attention to this. North Korea is paying attention to this."

Added Sen. Saxby Chambliss, R-Ga.: "For America to sit on the sidelines and do nothing is a huge mistake."

Obama has insisted that any use of chemical weapons would change his thinking about the United States' role in Syria but said he didn't have enough information to order aggressive action.

"For the Syrian government to utilize chemical weapons on its people crosses a line that will change my calculus and how the United States approaches these issues," Obama said Friday.

But Rep. Jan Schakowsky, an Illinois Democrat, said Sunday the United States needs to consider those weapons. She said that when Assad leaves power, his opponents could have access to those weapons or they could fall into the hands of U.S. enemies.

"The day after Assad is the day that these chemical weapons could be at risk ... (and) we could be in bigger, even bigger trouble," she said.

Both sides of the civil war already accuse each other of using the chemical weapons.

The deadliest such alleged attack was in the Khan al-Assal village in the Aleppo province in March. The Syrian government called for the United Nations to investigate alleged chemical weapons use by rebels in the attack that killed 31 people.

Syria, however, has not allowed a team of experts into the country because it wants the investigation limited to the single Khan al-Assal incident, while U.N. Secretary-General Ban Ki-moon has urged "immediate and unfettered access" for an expanded investigation.

One of Obama's chief antagonists on Syria, Sen. John McCain, R- Ariz., said the United States should go to Syria as part of an international force to safeguard the chemical weapons. But McCain added that he is not advocating sending ground troops to the nation.

"The worst thing the United States could do right now is put boots on the ground on Syria. That would turn the people against us," McCain said.

His friend, Sen. Lindsey Graham, R-S.C., also said the United States could safeguard the weapons without a ground force. But he cautioned the weapons must be protected for fear that Americans could be targeted. Raising the specter of the lethal bomb at the finish line of the Boston Marathon, Graham said the next attack on U.S. soil could employ weapons that were once part of Assad's arsenal.

"Chemical weapons ? enough to kill millions of people ? are going to be compromised and fall into the wrong hands, and the next bomb that goes off in America may not have nails and glass in it," he said.

Rogers and Schakowsky spoke to ABC's "This Week." Chambliss and Graham were interviewed on CBS's "Face the Nation." McCain appeared on NBC's "Meet the Press."

___

Follow Philip Elliott on Twitter: https://twitter.com/Philip_Elliott

Source: http://news.yahoo.com/lawmakers-syria-chemical-weapons-could-menace-us-154735931.html

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Robert Pattinson & Kristen Stewart Talking Marriage?

Robert Pattinson & Kristen Stewart Talking Marriage?

Robert Pattinson & Kristen Stewart wedding?Kristen Stewart has reportedly told close pals that she is ready to settle down with her “Twilight” co-star Robert Pattinson. The 23-year-old actress confessed she plans to tie the knot with Pattinson while they hung out with friends at the Coachella Festival earlier this month. So are Kristen and Robert hearing wedding bells? Kristen Stewart ...

Robert Pattinson & Kristen Stewart Talking Marriage? Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/04/robert-pattinson-kristen-stewart-talking-marriage/

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রবিবার, ২৮ এপ্রিল, ২০১৩

4 service members die in Afghanistan plane crash

* Lewandowski scored four goals against Real Madrid * Poland international refuses contract extension (adds details, background) BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another imminent surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief statement. ...

Source: http://news.yahoo.com/4-members-die-afghanistan-plane-crash-163748705.html

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Overseer of US victim funds says work wrenching (Providence Journal)

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PFT: Rodgers took less to help Packers' cap space

NFL Draft FootballAP

Another NFL Draft is in the books, 254 new players with a chance to create a professional future, and 32 teams delighted for the moment with the work they?ve done.

And while there were an abundance of storylines, one thing that stood out about the 2013 NFL Draft was the remarkable restraint many teams showed.

There wasn?t an Andrew Luck or a Cam Newton ? or perhaps even a Ryan Mallett ??in this draft.

But even with the extreme financial penalty for missing on a first-round passer gone, teams didn?t line up to take the chance on a potential franchise quarterback as they have in the past.?Only three quarterbacks were chosen in the first three rounds, the fewest since 2000 (the fabled Chad Pennington-Giovanni Carmazzi-Chris Redman draft).

The Bills fooled us all by taking E.J. Manuel in the first round, and even the Jets withstood the temptation to win the back pages by taking Geno Smith in the second. When Mike Glennon was the only third-rounder, it left names such as Matt Barkley and Ryan Nassib for the fourth, where the Eagles and Giants bought low.

Some of the best quarterback business was done by teams that didn?t take one.

The Jaguars might be more needy at the position than any team in the league, with Blaine Gabbert and Chad Henne competing. But as bad as that might be, there?s no guarantee any of this year?s candidates are better. So since new general manager David Caldwell didn?t see value, he withstood temptation and restocked a bad team with many other parts they needed ? most of them with speed.

But it wasn?t just at the quarterback position where the smart teams held fast.

After an unprecedented run on left tackles (three of the top four picks), teams with needs there started drafting guards and right tackles and defensive tackles instead of reaching. It would have been easy for the Chargers to move up for one of the top blind-side protectors, but by letting the board come to them, they found a solid starting right tackle in D.J. Fluker. Likewise, Arizona added a guard in Jonathan Cooper who could turn out to be the best value in the draft, and the Titans made Chris Johnson a better running back by drafting guard Chance Warmack (and center Brian Schwenke) to go with big-ticket free agent Andy Levitre.

And not to beat up on Manti Te?o any more than has already happened, the teams that needed him and didn?t draft him deserved notice as well.

The Vikings had a pair of late firsts, and used them on value picks Sharrif Floyd and Xavier Rhodes, both of whom figured to go sooner. Then they made a move for a third first-rounder, not for Te?o, but to take a receiver in Cordarrelle Patterson who has some Randy Moss-ish tendencies. The Bears also skipped an obvious need for a middle linebacker, and took a versatile but raw offensive lineman with good genes (Kyle Long).

The two Super Bowl teams (and two that should push them) exemplified the patience of the weekend as well.

The 49ers stockpiled picks, and used one on running back Marcus Lattimore, who might not play a down for them this year. The Ravens might have had interest in Te?o as well, but took their safety first (Matt Elam) before filling in at linebacker later (Arthur Brown).

The Packers added two running backs in Eddie Lacy and Johnathan Franklin who could make a good team better, and the Seahawks used the benefit of a roster with few holes to take some chances on players with question marks, from running back Christine Michael to defensive tackle Jesse Williams.

Not every team has such luxuries. But the best things might come to the ones that were able and willing to wait this weekend.

Source: http://profootballtalk.nbcsports.com/2013/04/27/crazy-as-it-sounds-rodgers-took-less/related/

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বুধবার, ১০ এপ্রিল, ২০১৩

No panic in NKorea despite talk of missile test

North Korean women pass by roadside propaganda depicting a North Korean soldier killing a U.S. soldier in Pyongyang, North Korea on Wednesday, April 10, 2013. The poster reads in Korean "Life or Death Battle. Merciless Punishment to U.S. Imperialists and Puppet Traitors." (AP Photo/David Guttenfelder)

North Korean women pass by roadside propaganda depicting a North Korean soldier killing a U.S. soldier in Pyongyang, North Korea on Wednesday, April 10, 2013. The poster reads in Korean "Life or Death Battle. Merciless Punishment to U.S. Imperialists and Puppet Traitors." (AP Photo/David Guttenfelder)

North Korean children carrying brooms walk on a sidewalk in Pyongyang on Wednesday, April 10, 2013, on their way to help tidy up the area around bronze statues of the late leaders as the capital city prepares to mark the April 15 birthday of its founder Kim Il Sung. (AP Photo/David Guttenfelder)

A North Korean soldier, center top, looks at the southern side as South Korean soldiers stand guard at the border village of Panmunjom, which has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Wednesday, April 10, 2013. The prospect of a North Korean missile launch is "considerably high," South Korea's foreign minister told lawmakers Wednesday as Pyongyang prepared to mark the April 15 birthday of its founder, historically a time when it seeks to draw the world's attention with dramatic displays of military power. (AP Photo/Lee Jin-man)

Young North Korean workers and students climb stairs to the base of bronze statues of the late leaders Kim Il Sung and Kim Jong Il during an event to pledge loyalty to the country in Pyongyang, North Korea on Wednesday, April 10, 2013. (AP Photo/David Guttenfelder)

North Korean pedestrians walk on a sidewalk past a large nationalist painting in Pyongyang, North Korea on Wednesday, April 10, 2013. (AP Photo/David Guttenfelder)

(AP) ? The prospect of a North Korean missile test is "considerably high," South Korea's foreign minister told lawmakers Wednesday as Pyongyang calmly prepared to mark the April 15 birthday of its founder, historically a time when it seeks to draw the world's attention with dramatic displays of military power.

The missile is expected to have a medium range, or about 3,500 kilometers (2,180 miles), which would allow it to fly over Japan, Foreign Minister Yun Byung-se told lawmakers in Seoul. Earlier, a Defense Ministry official said preparations appeared to be complete, and that the launch could take place at any time.

Yun said Seoul was bracing for the test-fire of a ballistic missile dubbed "Musudan" by foreign experts after the name of the northeastern village where North Korea has a launch pad. Experts said the Musudan is mainly designed to reach the U.S. territory of Guam though it can also place U.S. military installations in Japan in its striking range.

North Korean officials have not announced plans to launch a missile, but have told foreign diplomats in Pyongyang that they will not be able to guarantee their safety starting Wednesday. Officials also have urged tourists in South Korea to take cover, warning that a nuclear war is imminent. However, most diplomats and foreign residents appeared to be staying put.

The threats are largely seen as rhetoric and an attempt by North Korea to scare foreigners into pressing their governments to pressure Washington and Seoul to change their policies toward Pyongyang, as well as to boost the military credentials of North Korea's young leader, Kim Jong Un. North Korea does not have diplomatic relations with the U.S. and South Korea, its foes during the Korean War of the 1950s.

On the streets of Pyongyang, the focus was less on preparing for war and more on beautifying the city ahead of the nation's biggest holiday. Soldiers laid blankets of sod to liven up a city still coming out of a long, cold winter; gardeners got down on their knees to plant flowers and trees, and students marched off to school ? ordinary springtime activities belying the high tensions.

Downtown, schoolchildren headed toward the towering statues of the two late leaders, Kim Il Sung and Kim Jong Il, dragging brooms behind them. The brooms are used to sweep the plaza where the bronze statues stand on a hilltop overlooking Pyongyang. A group of women with coats thrown over traditional dresses rushed through the spring chill after leaving a rehearsal for a dance set to take place for Kim Il Sung's birthday celebrations.

At the base of Mansu Hill, a group of young people held a small rally to pledge their loyalty to Kim Jong Un and to sing the Kim ode "We Will Defend the Marshal With Our Lives."

Kim Un Chol, the 40-year-old head of a political unit at Pyongyang's tobacco factory, said he had been discharged from the military but was willing to re-enlist if war breaks out. He said North Koreans were resolute.

"The people of Pyongyang are confident. They know we can win any war," he told The Associated Press. "We now have nuclear weapons. So you won't see any worry on people's faces, even if the situation is tense."

North Korea sporadically holds civil air raid drills during which citizens practice blacking out their windows and seeking shelter. But no such drills have been held in recent months, local residents said.

Last year, the days surrounding the centennial of the birth of Kim Il Sung, grandfather of the current ruler, were marked by parades of tanks, goose-stepping soldiers and missiles, as well as the failed launch of a satellite-carrying rocket widely believed by the U.S. and its allies in the West to be a test of ballistic missile technology. A subsequent test in December went off successfully, and that was followed by the country's third underground nuclear test on Feb. 12 this year, possibly taking the regime closer to mastering the technology for mounting an atomic bomb on a missile.

The resulting U.N. sanctions and this spring's annual U.S.-South Korean military drills have been met with an unending string of threats and provocations from the North.

Adm. Samuel Locklear, commander of U.S. Pacific Command, told the Senate Armed Services Committee in Washington on Tuesday that North Korea's persistent nuclear and missile programs and threats have created "an environment marked by the potential for miscalculation."

He said the U.S. military and its allies would be ready if North Korea tries to strike.

North Korea has been escalating tensions with the U.S. and South Korea, its wartime foes, for months. The tightened U.N. sanctions that followed the nuclear test drew the ire of North Korea, which accused Washington and Seoul of leading the campaign against it. Annual U.S.-South Korean military drills south of the border have further incensed Pyongyang, which sees them as practice for an invasion.

Last week, Kim Jong Un enshrined the pursuit of nuclear weapons ? which the North characterizes as a defense against the U.S. ? as a national goal, along with improving the economy. North Korea also declared it would restart a mothballed nuclear complex.

Citing the tensions with Seoul, North Korea on Monday pulled more than 50,000 workers from the Kaesong industrial park, which combines South Korean technology and know-how with cheap North Korean labor. It was the first time that production was stopped at the decade-old factory park, the only remaining symbol of economic cooperation between the Koreas.

A test-fire of the Musudan missile would violate U.N. Security Council resolutions banning North Korea from nuclear and missile activity, and escalate tensions with the U.S., South Korea and Japan.

Japan has deployed PAC-3 missile interceptors in key locations around Tokyo.

The South Korean and U.S. militaries also have raised their surveillance level, called Watch Condition, a South Korean Defense Ministry official said. He refused to confirm a Yonhap News Agency report in Seoul saying it had been raised to 2, the second-highest level. He spoke on condition of anonymity, saying he wasn't authorized to speak to media.

One historian, James Person, noted that it isn't the first time North Korea has warned that a war was imminent.

He said that in 1968, following North Korea's seizure of an American ship, the USS Pueblo, Pyongyang persistently advised foreign diplomats to prepare for a U.S. counterattack. Cables from the Romanian mission in Pyongyang showed embassies were instructed to build anti-air bunkers "to protect foreigners against air attacks," he said.

The cables were obtained and posted online by the Wilson Center's North Korea International Documentation Project.

Person called it one of North Korea's first forays into what he dubs "military adventurism."

"In 1968, there was some concern there would be an attack, but (the North Koreans) certainly were building it up to be more than it was in hopes of getting more assistance from their allies at the time," Person said by phone from Alexandria, Virginia.

"I think much of it was hot air then. Today, I think again, it's more hot air," he said. "The idea is to scare people into pressuring the United States to return to negotiations with North Korea. That's the bottom line."

___

Kim reported from Seoul, South Korea. Kim Kwang Hyon and David Guttenfelder in Pyongyang and Matthew Pennington, Donna Cassata and Richard Lardner in Washington, D.C., contributed to this report.

___

Follow AP's Korea bureau chief on Twitter at twitter.com/newsjean.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-10-AS-Koreas-Tension/id-d537df5cfd8448f1bc17efcb9a4afe52

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Louvre Museum shuts for day as guards protest pickpockets

PARIS (Reuters) - Tourists caught no glimpse of the Mona Lisa, Winged Victory or Venus de Milo on Wednesday due to a one-day closure of the Louvre, as guards protested that pickpockets were rampant at the world's most visited museum.

Two hundred museum guards exercised their right to a work stoppage, forcing the museum to shut its doors for the day, union representatives said.

The CGT union said guards were "fed up" by attacks and threats directed at them and visitors over the past few months by pickpockets.

The secretary general of the national union for museums (SNMD), David Maillard, said petty thieves were multiplying at the site, visited by nearly 9 million people each year.

"There are thefts and threats every day. The guards are fed up with being assaulted by pickpockets," Maillard told Reuters, adding that the unions want better security at the museum.

The Louvre, which confirmed the closure on its website, could not be immediately reached for comment, but unions said the museum would reopen on Thursday.

Paris police regularly patrol the city's most crowded tourist sites, such as the Eiffel Tower and the Louvre.

But thieves who often operate in organized gangs are a constant frustration for authorities as they are easily able to exploit tourists and can lose themselves in crowds.

Many of those arrested do not hold French nationality or are minors, complicating judicial pursuit.

The Louvre posts signs warning against pickpockets at its entrances.

(Reporting By Alexandria Sage and Marion Douet; Writing by Alexandria Sage; Editing by Michael Roddy)

Source: http://news.yahoo.com/louvre-museum-shuts-day-guards-protest-pickpockets-172040579.html

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92% The Gatekeepers

All Critics (74) | Top Critics (30) | Fresh (68) | Rotten (6)

The film and its talking head participants paint the picture in both broad strokes and fine detail.

Whatever one's political stripe regarding Israel, it's hard to dispute the impressions and perspective of the film's six eyewitnesses.

The level of candor here may not satisfy hard-liners of either stripe, but it can help viewers begin to formulate new questions about the philosophical, strategic and moral challenges of conflict, in particular "wars on terror."

Ultimately the movie feels evasive, and its flashy, digitally animated re-creations of military surveillance footage unpleasantly evoke the Call of Duty video games.

It offers startlingly honest insight into the Israeli-Palestinian conflict from some of those who called the shots.

As a political testament, the result is revealing and important.

Insightful, revelatory and profound, Moreh's Oscar-nominated documentary combines riveting interviews, archive footage and - yes - state-of-the-art photographic effects to offer a unique perspective on the Israel-Palestine issue.

Both journalistic coup and unsettling confirmation of the idea that 'you can't make peace using military means.'

Much like Errol Morris' "The Fog of War," Dror Moreh's film is a sobering inside look inside history, at mistakes made and opportunities missed.

Moreh employs a direct interviewing style, reminiscent of Errol Morris' work, to get the men to talk about their days leading Shin Bet.

Moreh gets some startling confessions and insights from each man but also misses the opportunity to truly challenge his subjects on their regard for democracy, basic human rights and their own accountability.

Director Dror Moreh doesn't rest on his scoop

A powerful look inside the Israeli defense establishment

A deadly serious and detailed examination of and meditation upon the Israeli-Palestinian conflict, The Gatekeepers makes no attempt to find a silver lining.

The rule of surveillance is to keep quiet and let others do the talking. The Oscar-nominated documentary The Gatekeepers flips the script, to astonishing effect, giving voice to the retired directors of Shin Bet, Israel's domestic intelligence agency.

An up-close and personal look at the psychology of war -- their war and, by extension, all war.

A riveting firsthand account of how legitimate security concerns can lead to policies considered extreme and even immoral by the people administering them.

Extraordinary...not only an engrossing first-hand account of Israel's Palestinian policies over time, but one that may have lessons to teach both Israeli leaders and other nations confronting those they identify as terrorists.

Unprecedented and deeply unsettling, it offers little hope for a lasting peace in that war-torn region.

For its candor and impact, deserves to be seen and discussed.

An often remarkable Israeli documentary about Shin Bet, the country's internal security agency.

Source: http://www.rottentomatoes.com/m/the_gatekeepers_2012/

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মঙ্গলবার, ৯ এপ্রিল, ২০১৩

'Pharmaceutical' approach boosts oil production from algae

Apr. 8, 2013 ? Taking an approach similar to that used for discovering new therapeutic drugs, chemists at the University of California, Davis, have found several compounds that can boost oil production by green microscopic algae, a potential source of biodiesel and other "green" fuels.

The work appears online in the journal Chemical Biology.

Microalgae are single-celled organisms that, like green plants, use photosynthesis to capture carbon dioxide and turn it into complex compounds, including oils and lipids. Marine algae species can be raised in saltwater ponds and so do not compete with food crops for land or fresh water.

"They can live in saltwater, they take sunlight and carbon dioxide as a building block, and make these long chains of oil that can be converted to biodiesel," said Annaliese Franz, assistant professor of chemistry and an author of the paper.

Franz, graduate students Megan Danielewicz, Diana Wong and Lisa Anderson, and undergraduate student Jordan Boothe screened 83 compounds for their effects on growth and oil production in four strains of microalgae. They identified several that could boost oil production by up to 85 percent, without decreasing growth.

Among the promising compounds were common antioxidants such as epigallocatechin gallate, found in green tea, and butylated hydroxyanisole (BHA), a common food preservative.

The team has carried out growth experiments in culture volumes of up to half a liter. They calculate that some of the chemicals they analyzed would be cost-effective when scaled up to a 50,000 liter pond. After oils have been extracted from the algae, the remaining mass can be processed for animal feed or other uses.

Franz came to UC Davis in 2007 with a background in pharmaceutical chemistry. Given the campus's emphasis on biofuels, she started thinking about applying high-throughput techniques used to screen for new drugs to looking for compounds that could affect microalgae.

The idea, Franz said, is to look for small molecules that can affect a metabolic pathway in a cell. By setting up large numbers of cell cultures and measuring a simple readout in each, it's possible to screen for large numbers of different compounds in a short time and home in on the most promising.

"The basic concept comes from the pharmaceutical industry, and it's been used for human cells, plants, yeast, but not so far for algae," she said.

"There are many cases where small molecules are having an effect to treat a disease, so it makes sense that if you can affect a pathway in a human for a disease, you can affect a pathway in an algal cell," Franz said.

Patents on the work are pending. The research was funded by Chevron Technology Ventures through a cooperative agreement with UC Davis.

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The above story is reprinted from materials provided by University of California - Davis.

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Journal Reference:

  1. Annaliese K. Franz, Megan A. Danielewicz, Diana M. Wong, Lisa A. Anderson, Jordan R. Boothe. Phenotypic Screening with Oleaginous Microalgae Reveals Modulators of Lipid Productivity. ACS Chemical Biology, 2013; : 130322131504001 DOI: 10.1021/cb300573r

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/J5Iv6vVkoLQ/130408152951.htm

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Brits Shocked at Easy Availability of Knives (Powerlineblog)

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সোমবার, ৮ এপ্রিল, ২০১৩

Toddler Outsmarts Shape-Sorting Game, is Genius

Source: http://www.thehollywoodgossip.com/2013/04/toddler-outsmarts-shape-sorting-game-is-genius/

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iTunes is out of date and out of touch ? so what's next?

I was at a Starbucks last weekend, and I grabbed one of those "Pick of the Week" cards, one for Jeremy Piven's new show. I felt a momentary flutter of excitement ? sweet, free TV episode! In HD! But then I realized that I would have to download some huge file, and even then, I could only watch the show on the device I downloaded it to.

The concept suddenly seemed awkward ... antiquated, even.

And if I liked what I saw? I could pay Apple $2.99 per episode for the privilege of downloading more huge files. As a paying subscriber of Netflix and Amazon Prime ? not to mention cable TV ? my final reaction was, "No thanks."

(If you want my free download, the code is YY3FTKPH3W4F ? it'll only work once, so first come, first served. If you missed that chance, you can also watch the first episode on your iPhone or iPad for free ... on the PBS app.)

The iTunes situation only gets worse with music. In a world where Pandora streaming radio is free and Spotify's $9.99-per-month anywhere music-on-demand service is a crazy good deal, why would anybody buy an album?

Take it from a music and movie lover who has probably spent far more money than you on iTunes: It's over! There are few reasons to pay for specific music and video files ? and still fewer reasons to download them to your hard drive and sit on them like some gigabyte-greedy dragon.

Apple will be able to milk online music sales for a while, but Netflix, Amazon and other streaming video services are already taking customers away from iTunes and its rent-or-buy download model. If Apple doesn't announce a plan at its annual Worldwide Developer Conference, it risks getting shoved aside in the digital media realm like it's being shoved aside in the smartphone business.

There is hope for Apple fans: CNet is reporting that the company is "close to striking a streaming deal with two of the major music labels" for a service that resembles Pandora. It might have extra features, like the ability to jump back to the beginning of a song, or buy the track you are listening to. This won't bring back those who have already gone to Spotify, but it's a step in the direction Apple needs to go, music-wise.

As for video, what Apple should do is revisit its abandoned streaming TV approach, and allow people who purchased movies to stream them from any registered iDevice. (At the moment, if I want to watch "The Return of the King" ? which I "own" on iTunes ? I have to commit to a 4.1GB download. Ugh.)

I say this is what Apple should do. What Apple probably will do (which is fine with me but not as great for Apple) is open Apple TV to more apps like Spotify and Amazon Video on Demand. They're already available on iPad, iPhone and, of course, Macs, so it only makes sense. If Apple doesn't mind me spending money on other services, provided I use them on Apple hardware, I'm OK with that. But sooner or later, all of those services will work equally well on an HTC phone or a Samsung tablet, and then what?

Don't give away your store, Apple. It's time to evolve.

Wilson Rothman is the Technology & Science editor at NBC News Digital. Catch up with him on Twitter at @wjrothman, and join our conversation on Facebook.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a6d8421/l/0L0Snbcnews0N0Ctechnology0Ctechnolog0Citunes0Eout0Edate0Eout0Etouch0Eso0Ewhats0Enext0E1B9232131/story01.htm

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Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control

Apr. 7, 2013 ? Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful.

In fact, the white muscle that increases with resistance training, age and diabetes helps keep blood sugar in check, the researchers showed.

In addition, the insights from the molecular pathways involved in this phenomenon and identified in the study may point the way to potential drug targets for obesity and metabolic disease.

"We wanted to figure out the relationship between muscle types and body metabolism, how the muscles were made, and also what kind of influence they have on diseases like type 2 diabetes," said Jiandie Lin, Life Sciences Institute faculty member and associate professor at the U-M Medical School.

Lin's findings are scheduled to be published online April 7 in Nature Medicine.

Much like poultry has light and dark meat, mammals have a range of muscles: red, white and those in between. Red muscle, which gets its color in part from mitochondria, prevails in people who engage in endurance training, such as marathon runners. White muscle dominates in the bodies of weightlifters and sprinters -- people who require short, intense bursts of energy.

"Most people are in the middle and have a mix of red and white," Lin said.

When you exercise, nerves signal your muscles to contract, and the muscle needs energy. In response to a signal to lift a heavy weight, white muscles use glycogen to generate adenosine triphosphate (ATP) -- energy the cells can use to complete the task. While this process, called glycolysis, can produce a lot of power for a short time, the glycogen fuel soon depletes.

However, if the brain tells the muscle to run a slow and steady long-distance race, the mitochondria in red muscles primarily use fat oxidation instead of glycogen breakdown to generate ATP. The supply of energy lasts much longer but doesn't provide the burst of strength that comes from glycolysis.

People with diabetes see whitening of the mix of muscle.

"For a long time, the red-to-white shift was thought to make muscle less responsive to insulin, a hormone that lowers blood sugar," Lin said. "But this idea is far from proven. You lose red muscle when you age or develop diabetes, but is that really the culprit?"

To find out, the team set out to find a protein that drives the formation of white muscle. They sifted through microarray data sets from public databases and identified a list of candidate proteins that were prevalent in white muscle but not in red.

Further studies led the team to focus on a protein called BAF60c, a sort of "zip code" mechanism that tells the cells when and how to express certain genes. The Lin team made a transgenic mouse model to increase BAF60c only in the skeletal muscle. One of the first things they noticed was that mice with more BAF60c had muscles that looked paler.

"That was a good hint that we were going in the white-muscle direction," said lead author Zhuo-xian Meng, a research fellow in Lin's lab.

They used electron microscopy to see the abundance of mitochondria within the muscle, and confirmed that muscle from BAF60c transgenic mice had less mitochondria than the normal controls.

"We saw predicted changes in molecular markers, but the ultimate test would be seeing how the mouse could run," Lin said.

If the BAF60c mice could run powerfully for short distances but tired quickly, the scientists would be able to confirm that the BAF60c pathway was a key part of the creation of white muscle.

Using mouse treadmills, they compared the endurance of BAF60c mice to a control group of normal mice, and found that the BAF60c transgenic mice could only run about 60 percent of the time that the control group could before tiring.

"White muscle uses glycogen, and the transgenic mice depleted their muscles' supplies of glycogen very quickly," Lin said.

After some follow-up experiments to figure out exactly which molecules were controlled by BAF60c, Lin and his team were confident that they had identified major players responsible for promoting white muscle formation. Now that they knew how to make more white muscle in animals, they wanted to determine whether white muscle was a deleterious or an adaptive characteristic of diabetes.

The team induced obesity in mice by feeding them the "Super Size Me" diet, Lin said. On a high-fat diet, a mouse will double its body weight in two to three months. They found that obese mice with BAF60c transgene were much better at controlling blood glucose.

"The results are a bit of a surprise to many people," Lin said. "It really points to the complexity in thinking about muscle metabolism and diabetes."

In humans, resistance training promotes the growth of white muscle and helps in lowering blood glucose. If future studies in humans determine that the BAF60c pathway is indeed the way in which cells form white muscle and in turn optimize metabolic function, the finding could lead to researching the pathway as a drug target.

"We know that this molecular pathway also works in human cells. The real challenge is to find a way to target these factors," Lin said.

Lin is a research faculty member of the Life Sciences Institute, where his laboratory is located and all his research is conducted. He is also an associate professor in the Department of Cell and Developmental Biology at the U-M Medical School.

Support for the research was provided by the Michigan Diabetes Research and Training Center, Nutrition Obesity Research Center, National Institutes of Health and the American Heart Association.

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The above story is reprinted from materials provided by University of Michigan.

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Journal Reference:

  1. Zhuo-Xian Meng, Siming Li, Lin Wang, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Mitsuharu Okutsu, Zhen Yan, Jason K Kim, Jiandie D Lin. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine, 2013; DOI: 10.1038/nm.3144

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/lUjP0ObjLMs/130407132914.htm

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রবিবার, ৭ এপ্রিল, ২০১৩

96% War Witch

All Critics (46) | Top Critics (16) | Fresh (44) | Rotten (2)

Canadian writer-director Kim Nguyen spent nearly a decade researching this docudrama about child soldiers in Africa, and the film feels as authoritative as a first-hand account.

A haunting take on unspeakably grim subject matter, shot on location in the Democratic Republic of Congo.

A powerful and upsetting portrait of a young girl compelled into unimaginably horrific circumstances.

Nguyen, astonishingly, manages to wring something vaguely like a happy ending from this tragic story.

War Witch is most effective not when we are looking in on Komona but when we are inside her head.

The powerful things we expect from "War Witch" are as advertised, but what we don't expect is even better.

You're likely to remember its images, its insights into a very foreign (for most of us) location and the tragic situation of Komona and others like her for a long time to come.

Is it accurate depiction of Africa's child soldiers? I don't know, thank God. But it feels authentic to its very core, and that makes it as hard to forget as it is to ignore.

Brutal without turning exploitative, the result is harrowing and heartbreaking.

Nguyen creates a mesmerizing tone through his camerawork, editing, sound and the infusion of African folk imagery and ritual, but it's Mwanza's performance as Komona that makes "War Witch" feel so miraculous.

Nguyen reportedly worked on "War Witch" for a decade, and it shows in both the immediacy and authenticity of his tale, and the meticulous craft with which it's told.

Made with extremely clear-eyed restraint from harangues, sentiment, message-mongering, or anything else that would cheapen its central character's suffering and fight.

War Witch features a standout performance by Rachel Mwanza, but the supernatural visions don't really suit the film's tone and mood.

Nguyen's compassion and commitment to the issue is admirable, and at its best, War Witch is devastating.

War Witch is remarkable for the fact that it never strays into sentimentality or sensationalism.

...a love story between youngsters who are forced to become adults all too early in their lives.

This is a straight ahead essay on warfare at its worst and the survival of the human spirit at its best.

An astonishing drama set in Africa that vividly depicts the courage and resiliency of a 12-year-old girl whose spiritual gifts enable her to survive.

It is astonishing that film that contains such violence can have such a serene tone. The source of the serenity is the measured, calm narration by Komona (voice of Diane Umawahoro) that is the telling of her story to her unborn child

An exquisitely made film in direct contrast to the ugliness of its subject matter

The portrait of a girl who retains her dignity and strength, her faith in the future, in the face of unimaginable horrors. It's inspirational in a very real way.

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Source: http://www.rottentomatoes.com/m/war_witch/

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98% 56 Up

All Critics (55) | Top Critics (22) | Fresh (54) | Rotten (1)

Yes, on some level it's just a seven-year check-in with people maybe half-remembered, if that. Yet the films also serve as a kind of check-in with us, too.

What ultimately is so compelling about 56 Up is the universality of the experiences. We were all once children. And we all will die. And in between, there is everything else.

We feel good, refreshed and depressed in watching these people get older, also embarrassed in moments and cautioned about the passage of time.

Apted, himself now in his early 70s, says he hopes to continue the series further. Long may it live.

Watching "56 Up" gives you the wonderful feeling of seeing a sociological experiment blossom into something novelistically rich and humane.

Time has been neither kind nor cruel to the 13 men and women profiled in "56 UP." It has just been time, which is what this groundbreaking series is about.

Chances are that you'll come away from this long film feeling a sense of knowing its characters.

We might say that '56 Up' serves much the same function as 'Amour,' but it responds to the inevitability of decline with compassion, not dread.

What started as a crafty way of looking at the U.K.'s rigid class structure has grown into a portrait of melancholy middle age, with its heartbreaks and minor-key triumphs.

Those British kids are now 56

Watching the eighth film is intriguing but, in a way, disappointing. At this point in the game, it feels as if all the characters have determined their lots in life and are simply plodding through their interviews.

Quite simply one of the great documentary projects in the history of cinema, an engrossing sociological experiment on film; and though this mostly mellow installment isn't as revelatory as some earlier ones, it's still a remarkable document.

... feels like a retrospective and summation of the whole series, with ample quotation from the previous films, an approach that makes it interesting even for viewers who haven't seen the previous installments.

A completely unique and remarkable documentary project.

Apted skillfully weaves old footage with the new, and we become poignantly aware of another factor shaping their lives (and our own): biology, as the we watch the once-cute kids grow gray and heavy.

Perhaps the boldest and probably longest running sociological experiment on film.

I think the best thing about this movie (and the entire series) is that it forces the viewer to think about their own lives. It's kind of an awakening experience.

Once again, Apted assembles a captivating documentary that's profoundly educational, essential viewing to aid the understanding of the human experience.

"56 Up" is well worth seeing.

56 Up is still moving and philosophic, though not as exciting as earlier episodes, which had more drama.

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Source: http://www.rottentomatoes.com/m/56_up/

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শনিবার, ৬ এপ্রিল, ২০১৩

Stocks end lower after disappointing jobs report

NEW YORK (AP) ? Stocks fell on Wall Street Friday after the government reported a sharp slowdown in hiring last month that was far worse than economists had expected.

The Dow Jones industrial average ended 40.86 points lower at 14,565.25, a loss of 0.3 percent. The index was down as much as 171 points in the early going, then rose gradually through the rest of the day to reclaim much of its early loss.

U.S. employers added just 88,000 jobs in March, the Labor Department reported. That's half the average of the previous six months. The report was a disappointment for investors following positive signs on housing and the job market over the winter.

The survey, one of the most closely watched indicators of the economy, dented investors' confidence that the U.S. was poised for a sustained recovery. The stock market has surged this year, pushing the Dow to another record high close on Tuesday. The index is still up 11.2 percent this year.

"Things are still looking decent, but there's no doubt that this was a bit of a disappointment," said Brad Sorensen, Charles Schwab's director of market and sector research. "We're watching to see: is this the start of another soft patch?"

In other trading, the Standard & Poor's 500 index fell 6.70 points, or 0.4 percent, to 1,553.28. The index logged its worst week of year, falling 1 percent.

Technology stocks fell the most of the 10 industry groups in the index, dropping 1 percent. Among big decliners in tech stocks, Cisco Systems fell 43 cents, or 2 percent, to $20.61. Oracle dropped 34 cents, or 1 percent, to $32.03.

Investors were reducing their exposure to risk. The utilities and telecommunications industries bucked the downward trend. Both rose 0.4 percent. The rich dividends and stable earnings provided by those companies make them attractive to investors who want to play it safe.

Natural gas companies were among the best performers on the S&P 500 as the price of the fuel rose 4.5 percent on concerns about supplies. The price of the fuel has risen 21 percent since the start of the year. Cabot Oil & Gas climbed $3.32, or 5.1 percent, to $67.96 and WPX Energy gained 80 cents, or 5.2 percent, to $16.15.

Stocks pared their early losses as some investors inferred that slowing U.S. growth meant that the Federal Reserve would stick to its stimulus program. The central bank is buying $85 billion dollars in bonds every month as part of an effort to revive the economy. Its actions have been a big factor pushing the stock market higher this year.

Quincy Krosby, a market strategist at Prudential Financial, said the slowdown in hiring made it more likely that the Fed would continue with its easy-money policy, which includes keeping interest rates at historically low levels.

Investors will shift their focus to earnings reports next week.

Alcoa, the first company in the Dow index to report earnings, will release its first-quarter financial results after the markets close Monday. Analysts expect profits for S&P 500 companies to rise 0.6 percent in the first quarter compared with the same period a year earlier, according to S&P Capital IQ. That compares with an increase of 7.7 percent in the fourth quarter of 2012.

The yield on the 10-year Treasury note, which moves inversely to its price, plunged from 1.76 percent to 1.71 percent. The yield fell as low as 1.69 percent, the lowest since December. The benchmark rate has declined sharply over the last month, from 2.06 percent on March 11, as demand for low-risk assets increased amid mounting evidence that growth in the U.S. economy is slowing.

Matthew Coffina, an editor at Morningstar StockInvestor, said stocks are still a better investment than bonds over the next decade because bonds will be vulnerable to any rise in inflation or interest rates. "We still have a strong preference for stocks," Coffina said.

The Nasdaq composite, which includes many technology companies, fell 21.12 points, or 0.7 percent, to 3,203.86.

F5 Networks, a network equipment and service provider based in Seattle, plunged 19 percent, the most of any S&P stock, after slashing its profit and revenue forecast. The company said its contract bookings fell sharply, as did its business with the federal government. The stock lost $17.21, or 19 percent, to $73.21.

The Dow Jones Transportation Average, which includes airlines like United and Delta Airlines and shipping companies like UPS and FedEx, was down 3.5 percent for the week, its biggest weekly decline since September. The index is seen as a leading indicator of the broader market.

Source: http://news.yahoo.com/stocks-end-lower-disappointing-jobs-report-205321034--finance.html

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