Source: http://www.thehollywoodgossip.com/2013/04/toddler-outsmarts-shape-sorting-game-is-genius/
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সোমবার, ৮ এপ্রিল, ২০১৩
iTunes is out of date and out of touch ? so what's next?
I was at a Starbucks last weekend, and I grabbed one of those "Pick of the Week" cards, one for Jeremy Piven's new show. I felt a momentary flutter of excitement ? sweet, free TV episode! In HD! But then I realized that I would have to download some huge file, and even then, I could only watch the show on the device I downloaded it to.
The concept suddenly seemed awkward ... antiquated, even.
And if I liked what I saw? I could pay Apple $2.99 per episode for the privilege of downloading more huge files. As a paying subscriber of Netflix and Amazon Prime ? not to mention cable TV ? my final reaction was, "No thanks."
(If you want my free download, the code is YY3FTKPH3W4F ? it'll only work once, so first come, first served. If you missed that chance, you can also watch the first episode on your iPhone or iPad for free ... on the PBS app.)
The iTunes situation only gets worse with music. In a world where Pandora streaming radio is free and Spotify's $9.99-per-month anywhere music-on-demand service is a crazy good deal, why would anybody buy an album?
Take it from a music and movie lover who has probably spent far more money than you on iTunes: It's over! There are few reasons to pay for specific music and video files ? and still fewer reasons to download them to your hard drive and sit on them like some gigabyte-greedy dragon.
Apple will be able to milk online music sales for a while, but Netflix, Amazon and other streaming video services are already taking customers away from iTunes and its rent-or-buy download model. If Apple doesn't announce a plan at its annual Worldwide Developer Conference, it risks getting shoved aside in the digital media realm like it's being shoved aside in the smartphone business.
There is hope for Apple fans: CNet is reporting that the company is "close to striking a streaming deal with two of the major music labels" for a service that resembles Pandora. It might have extra features, like the ability to jump back to the beginning of a song, or buy the track you are listening to. This won't bring back those who have already gone to Spotify, but it's a step in the direction Apple needs to go, music-wise.
As for video, what Apple should do is revisit its abandoned streaming TV approach, and allow people who purchased movies to stream them from any registered iDevice. (At the moment, if I want to watch "The Return of the King" ? which I "own" on iTunes ? I have to commit to a 4.1GB download. Ugh.)
I say this is what Apple should do. What Apple probably will do (which is fine with me but not as great for Apple) is open Apple TV to more apps like Spotify and Amazon Video on Demand. They're already available on iPad, iPhone and, of course, Macs, so it only makes sense. If Apple doesn't mind me spending money on other services, provided I use them on Apple hardware, I'm OK with that. But sooner or later, all of those services will work equally well on an HTC phone or a Samsung tablet, and then what?
Don't give away your store, Apple. It's time to evolve.
Wilson Rothman is the Technology & Science editor at NBC News Digital. Catch up with him on Twitter at @wjrothman, and join our conversation on Facebook.
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Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
Apr. 7, 2013 ? Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful.
In fact, the white muscle that increases with resistance training, age and diabetes helps keep blood sugar in check, the researchers showed.
In addition, the insights from the molecular pathways involved in this phenomenon and identified in the study may point the way to potential drug targets for obesity and metabolic disease.
"We wanted to figure out the relationship between muscle types and body metabolism, how the muscles were made, and also what kind of influence they have on diseases like type 2 diabetes," said Jiandie Lin, Life Sciences Institute faculty member and associate professor at the U-M Medical School.
Lin's findings are scheduled to be published online April 7 in Nature Medicine.
Much like poultry has light and dark meat, mammals have a range of muscles: red, white and those in between. Red muscle, which gets its color in part from mitochondria, prevails in people who engage in endurance training, such as marathon runners. White muscle dominates in the bodies of weightlifters and sprinters -- people who require short, intense bursts of energy.
"Most people are in the middle and have a mix of red and white," Lin said.
When you exercise, nerves signal your muscles to contract, and the muscle needs energy. In response to a signal to lift a heavy weight, white muscles use glycogen to generate adenosine triphosphate (ATP) -- energy the cells can use to complete the task. While this process, called glycolysis, can produce a lot of power for a short time, the glycogen fuel soon depletes.
However, if the brain tells the muscle to run a slow and steady long-distance race, the mitochondria in red muscles primarily use fat oxidation instead of glycogen breakdown to generate ATP. The supply of energy lasts much longer but doesn't provide the burst of strength that comes from glycolysis.
People with diabetes see whitening of the mix of muscle.
"For a long time, the red-to-white shift was thought to make muscle less responsive to insulin, a hormone that lowers blood sugar," Lin said. "But this idea is far from proven. You lose red muscle when you age or develop diabetes, but is that really the culprit?"
To find out, the team set out to find a protein that drives the formation of white muscle. They sifted through microarray data sets from public databases and identified a list of candidate proteins that were prevalent in white muscle but not in red.
Further studies led the team to focus on a protein called BAF60c, a sort of "zip code" mechanism that tells the cells when and how to express certain genes. The Lin team made a transgenic mouse model to increase BAF60c only in the skeletal muscle. One of the first things they noticed was that mice with more BAF60c had muscles that looked paler.
"That was a good hint that we were going in the white-muscle direction," said lead author Zhuo-xian Meng, a research fellow in Lin's lab.
They used electron microscopy to see the abundance of mitochondria within the muscle, and confirmed that muscle from BAF60c transgenic mice had less mitochondria than the normal controls.
"We saw predicted changes in molecular markers, but the ultimate test would be seeing how the mouse could run," Lin said.
If the BAF60c mice could run powerfully for short distances but tired quickly, the scientists would be able to confirm that the BAF60c pathway was a key part of the creation of white muscle.
Using mouse treadmills, they compared the endurance of BAF60c mice to a control group of normal mice, and found that the BAF60c transgenic mice could only run about 60 percent of the time that the control group could before tiring.
"White muscle uses glycogen, and the transgenic mice depleted their muscles' supplies of glycogen very quickly," Lin said.
After some follow-up experiments to figure out exactly which molecules were controlled by BAF60c, Lin and his team were confident that they had identified major players responsible for promoting white muscle formation. Now that they knew how to make more white muscle in animals, they wanted to determine whether white muscle was a deleterious or an adaptive characteristic of diabetes.
The team induced obesity in mice by feeding them the "Super Size Me" diet, Lin said. On a high-fat diet, a mouse will double its body weight in two to three months. They found that obese mice with BAF60c transgene were much better at controlling blood glucose.
"The results are a bit of a surprise to many people," Lin said. "It really points to the complexity in thinking about muscle metabolism and diabetes."
In humans, resistance training promotes the growth of white muscle and helps in lowering blood glucose. If future studies in humans determine that the BAF60c pathway is indeed the way in which cells form white muscle and in turn optimize metabolic function, the finding could lead to researching the pathway as a drug target.
"We know that this molecular pathway also works in human cells. The real challenge is to find a way to target these factors," Lin said.
Lin is a research faculty member of the Life Sciences Institute, where his laboratory is located and all his research is conducted. He is also an associate professor in the Department of Cell and Developmental Biology at the U-M Medical School.
Support for the research was provided by the Michigan Diabetes Research and Training Center, Nutrition Obesity Research Center, National Institutes of Health and the American Heart Association.
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The above story is reprinted from materials provided by University of Michigan.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Zhuo-Xian Meng, Siming Li, Lin Wang, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Mitsuharu Okutsu, Zhen Yan, Jason K Kim, Jiandie D Lin. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine, 2013; DOI: 10.1038/nm.3144
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/lUjP0ObjLMs/130407132914.htm
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রবিবার, ৭ এপ্রিল, ২০১৩
96% War Witch
All Critics (46) | Top Critics (16) | Fresh (44) | Rotten (2)
Canadian writer-director Kim Nguyen spent nearly a decade researching this docudrama about child soldiers in Africa, and the film feels as authoritative as a first-hand account.
A haunting take on unspeakably grim subject matter, shot on location in the Democratic Republic of Congo.
A powerful and upsetting portrait of a young girl compelled into unimaginably horrific circumstances.
Nguyen, astonishingly, manages to wring something vaguely like a happy ending from this tragic story.
War Witch is most effective not when we are looking in on Komona but when we are inside her head.
The powerful things we expect from "War Witch" are as advertised, but what we don't expect is even better.
You're likely to remember its images, its insights into a very foreign (for most of us) location and the tragic situation of Komona and others like her for a long time to come.
Is it accurate depiction of Africa's child soldiers? I don't know, thank God. But it feels authentic to its very core, and that makes it as hard to forget as it is to ignore.
Brutal without turning exploitative, the result is harrowing and heartbreaking.
Nguyen creates a mesmerizing tone through his camerawork, editing, sound and the infusion of African folk imagery and ritual, but it's Mwanza's performance as Komona that makes "War Witch" feel so miraculous.
Nguyen reportedly worked on "War Witch" for a decade, and it shows in both the immediacy and authenticity of his tale, and the meticulous craft with which it's told.
Made with extremely clear-eyed restraint from harangues, sentiment, message-mongering, or anything else that would cheapen its central character's suffering and fight.
War Witch features a standout performance by Rachel Mwanza, but the supernatural visions don't really suit the film's tone and mood.
Nguyen's compassion and commitment to the issue is admirable, and at its best, War Witch is devastating.
War Witch is remarkable for the fact that it never strays into sentimentality or sensationalism.
...a love story between youngsters who are forced to become adults all too early in their lives.
This is a straight ahead essay on warfare at its worst and the survival of the human spirit at its best.
An astonishing drama set in Africa that vividly depicts the courage and resiliency of a 12-year-old girl whose spiritual gifts enable her to survive.
It is astonishing that film that contains such violence can have such a serene tone. The source of the serenity is the measured, calm narration by Komona (voice of Diane Umawahoro) that is the telling of her story to her unborn child
An exquisitely made film in direct contrast to the ugliness of its subject matter
The portrait of a girl who retains her dignity and strength, her faith in the future, in the face of unimaginable horrors. It's inspirational in a very real way.
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Source: http://www.rottentomatoes.com/m/war_witch/
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98% 56 Up
All Critics (55) | Top Critics (22) | Fresh (54) | Rotten (1)
Yes, on some level it's just a seven-year check-in with people maybe half-remembered, if that. Yet the films also serve as a kind of check-in with us, too.
What ultimately is so compelling about 56 Up is the universality of the experiences. We were all once children. And we all will die. And in between, there is everything else.
We feel good, refreshed and depressed in watching these people get older, also embarrassed in moments and cautioned about the passage of time.
Apted, himself now in his early 70s, says he hopes to continue the series further. Long may it live.
Watching "56 Up" gives you the wonderful feeling of seeing a sociological experiment blossom into something novelistically rich and humane.
Time has been neither kind nor cruel to the 13 men and women profiled in "56 UP." It has just been time, which is what this groundbreaking series is about.
Chances are that you'll come away from this long film feeling a sense of knowing its characters.
We might say that '56 Up' serves much the same function as 'Amour,' but it responds to the inevitability of decline with compassion, not dread.
What started as a crafty way of looking at the U.K.'s rigid class structure has grown into a portrait of melancholy middle age, with its heartbreaks and minor-key triumphs.
Those British kids are now 56
Watching the eighth film is intriguing but, in a way, disappointing. At this point in the game, it feels as if all the characters have determined their lots in life and are simply plodding through their interviews.
Quite simply one of the great documentary projects in the history of cinema, an engrossing sociological experiment on film; and though this mostly mellow installment isn't as revelatory as some earlier ones, it's still a remarkable document.
... feels like a retrospective and summation of the whole series, with ample quotation from the previous films, an approach that makes it interesting even for viewers who haven't seen the previous installments.
A completely unique and remarkable documentary project.
Apted skillfully weaves old footage with the new, and we become poignantly aware of another factor shaping their lives (and our own): biology, as the we watch the once-cute kids grow gray and heavy.
Perhaps the boldest and probably longest running sociological experiment on film.
I think the best thing about this movie (and the entire series) is that it forces the viewer to think about their own lives. It's kind of an awakening experience.
Once again, Apted assembles a captivating documentary that's profoundly educational, essential viewing to aid the understanding of the human experience.
"56 Up" is well worth seeing.
56 Up is still moving and philosophic, though not as exciting as earlier episodes, which had more drama.
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Source: http://www.rottentomatoes.com/m/56_up/
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শনিবার, ৬ এপ্রিল, ২০১৩
Stocks end lower after disappointing jobs report
NEW YORK (AP) ? Stocks fell on Wall Street Friday after the government reported a sharp slowdown in hiring last month that was far worse than economists had expected.
The Dow Jones industrial average ended 40.86 points lower at 14,565.25, a loss of 0.3 percent. The index was down as much as 171 points in the early going, then rose gradually through the rest of the day to reclaim much of its early loss.
U.S. employers added just 88,000 jobs in March, the Labor Department reported. That's half the average of the previous six months. The report was a disappointment for investors following positive signs on housing and the job market over the winter.
The survey, one of the most closely watched indicators of the economy, dented investors' confidence that the U.S. was poised for a sustained recovery. The stock market has surged this year, pushing the Dow to another record high close on Tuesday. The index is still up 11.2 percent this year.
"Things are still looking decent, but there's no doubt that this was a bit of a disappointment," said Brad Sorensen, Charles Schwab's director of market and sector research. "We're watching to see: is this the start of another soft patch?"
In other trading, the Standard & Poor's 500 index fell 6.70 points, or 0.4 percent, to 1,553.28. The index logged its worst week of year, falling 1 percent.
Technology stocks fell the most of the 10 industry groups in the index, dropping 1 percent. Among big decliners in tech stocks, Cisco Systems fell 43 cents, or 2 percent, to $20.61. Oracle dropped 34 cents, or 1 percent, to $32.03.
Investors were reducing their exposure to risk. The utilities and telecommunications industries bucked the downward trend. Both rose 0.4 percent. The rich dividends and stable earnings provided by those companies make them attractive to investors who want to play it safe.
Natural gas companies were among the best performers on the S&P 500 as the price of the fuel rose 4.5 percent on concerns about supplies. The price of the fuel has risen 21 percent since the start of the year. Cabot Oil & Gas climbed $3.32, or 5.1 percent, to $67.96 and WPX Energy gained 80 cents, or 5.2 percent, to $16.15.
Stocks pared their early losses as some investors inferred that slowing U.S. growth meant that the Federal Reserve would stick to its stimulus program. The central bank is buying $85 billion dollars in bonds every month as part of an effort to revive the economy. Its actions have been a big factor pushing the stock market higher this year.
Quincy Krosby, a market strategist at Prudential Financial, said the slowdown in hiring made it more likely that the Fed would continue with its easy-money policy, which includes keeping interest rates at historically low levels.
Investors will shift their focus to earnings reports next week.
Alcoa, the first company in the Dow index to report earnings, will release its first-quarter financial results after the markets close Monday. Analysts expect profits for S&P 500 companies to rise 0.6 percent in the first quarter compared with the same period a year earlier, according to S&P Capital IQ. That compares with an increase of 7.7 percent in the fourth quarter of 2012.
The yield on the 10-year Treasury note, which moves inversely to its price, plunged from 1.76 percent to 1.71 percent. The yield fell as low as 1.69 percent, the lowest since December. The benchmark rate has declined sharply over the last month, from 2.06 percent on March 11, as demand for low-risk assets increased amid mounting evidence that growth in the U.S. economy is slowing.
Matthew Coffina, an editor at Morningstar StockInvestor, said stocks are still a better investment than bonds over the next decade because bonds will be vulnerable to any rise in inflation or interest rates. "We still have a strong preference for stocks," Coffina said.
The Nasdaq composite, which includes many technology companies, fell 21.12 points, or 0.7 percent, to 3,203.86.
F5 Networks, a network equipment and service provider based in Seattle, plunged 19 percent, the most of any S&P stock, after slashing its profit and revenue forecast. The company said its contract bookings fell sharply, as did its business with the federal government. The stock lost $17.21, or 19 percent, to $73.21.
The Dow Jones Transportation Average, which includes airlines like United and Delta Airlines and shipping companies like UPS and FedEx, was down 3.5 percent for the week, its biggest weekly decline since September. The index is seen as a leading indicator of the broader market.
Source: http://news.yahoo.com/stocks-end-lower-disappointing-jobs-report-205321034--finance.html
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Samsung starts rolling out Android 4.1.2 update to Galaxy Tab 7.0 Plus
Good news for Samsung Galaxy Tab 7.0 Plus owners. According to SamMobile, Samsung has started rolling out the Android 4.1.2 Jelly Bean update to this tablet.
The first country to receive this update is Austria, however, other regions should be getting the updates shortly. As usual, the Jelly Bean update would bring features such as Project Butter, Google Now and several other improvements under the hood.
If you are a Tab 7.0 Plus owner, check to see if the update is available in your region.
Source
Source: http://blog.gsmarena.com/samsung-starts-rolling-out-android-4-1-2-update-to-galaxy-tab-7-0/
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